Analysis of TCR signatures predicts

2018-10-20

Analysis of TCRβ signatures predicts that several initial “founder” clones of iPSC were present at P4 but that these resolved to a single clone by P20. This was somewhat surprising, as it is often assumed that individually picked colonies of iPSC are derived from a single cell and are therefore clon

Finally an important practical implication of our data is

2018-10-20

Finally, an important practical implication of our data is that both fibroblasts and blood can be used for the generation of comparable iPSC lines for large-scale biobanking purposes (Figure 6). Our results demonstrate that variability among small cohorts of iPSCs may lead to erroneous conclusions (

Main Text br Acknowledgments I have

2018-10-20

Main Text Acknowledgments I have been fortunate to work with tremendous mentors, colleagues, and students throughout my career and I am grateful for their past and current support. Research in my laboratory is supported by the NIH, the New York Stem Cell Foundation as a New York Stem Cell Founda

br Results br Discussion The Wnt signaling

2018-10-20

Results Discussion The Wnt signaling pathway has emerged as the dominant self-renewal pathway for various adult-type stem cells and is required for maintenance of embryonic as well as induced pluripotent stem cells. In the hematopoietic system, only mild increased Wnt dosages result in higher

br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We wish to thank the cytometer unit of CABIMER for technical support, Diana Aguilar for critical reading of the manuscript, and Veronica Raker for style corrections. This work was funded by an R + D + I grant from the Spanish Mini

Hello world!

2018-07-29