• br Acknowledgments We thank Florence Le Calvez Kelm and

  2018-10-22

  

  Acknowledgments We thank Florence Le Calvez-Kelm and Geoffroy Durand from IARC\'s Genetics Platform (GPS) and Fabienne Barbet from the ProfileXpert platform for the processing and scanning of the Illumina 450K arrays. P.-B.A. was supported by la Ligue National (Française) Contre le Cancer. S.E. i

• We also observed that months after H Thy incorporation

  2018-10-22

  

  We also observed that 2 months after 3H-Thy incorporation, none of the V-SVZ LRCs exhibited ELCS in their nuclei. The number of interleukin 2 receptor exhibiting ELCS greatly decreased with age. Consistently, other reports have shown a decrease in the neurogenic potential with age (Bouab et al., 20

• Posttranscriptional regulation is usually mediated by the in

  2018-10-22

  

  Posttranscriptional regulation is usually mediated by the interaction of trans-acting factors with the UTR regions. Thus, 3′UTRs appear to play a key role in posttranscriptional regulation, as the spatial platform bearing the sequence or structural elements in cis that are targeted by regulatory fac

• br Acknowledgments This work was supported by the

  2018-10-20

  

  Acknowledgments This work was supported by the Agency for Science, Technology and Research, Singapore. We would like to thank the Cytogenetics laboratory at Singapore General Hospital for karyotyping the iPSC lines and Luqman Hakim for help in characterizing the iPSC lines. We would like to thank

• sphingosine-1-phosphate In the present study we examined the

  2018-10-20

  

  In the present study, we examined the above-mentioned properties of MSC-derived exosomes to limit cell death after myocardial I/R injury in vivo. We show that intact exosomes directly target cardiac sphingosine-1-phosphate to reduce infarct size. Furthermore, we demonstrate that, in line with our i

• nebivolol hcl The identification of stem cells or progenitor

  2018-10-20

  

  The identification of stem nebivolol hcl or progenitor cells, and their contribution to pancreatic regeneration remain controversial (Ziv et al., 2013; Burke and Tosh, 2012). The pancreas uses several regenerative mechanisms. Self-renewal is the principal mechanism of acinar and islet regeneration

• br Materials and methods br Results Teeth were collected

  2018-10-20

  

  Materials and methods Results Teeth were collected from 10 female and 6 male subjects. The subject ages ranged from 6 to 13years old, with an average age of 9. All subjects were typically developing children with no suspicion of undiagnosed neurogenetic disorders. The teeth included in the stu

• congo red br Resource table Resource details

  2018-10-20

  

  Resource table. Resource details RCe008-A (RC-4) was derived from a fresh congo red that was surplus to requirement or unsuitable for clinical use. The cell line was derived by whole embryo outgrowth on a chemically defined matrix consisting of laminin, fibronectin, Collagen IV and vitronectin (

• We recently reported that iPSCs can

  2018-10-20

  

  We recently reported that iPSCs can be generated using non-modified mRNA (Arnold et al., 2012). In this report we will focus on the crucial steps for successfully applying this method. Material and methods Results Discussion Acknowledgments The work was supported by funding from the Ger

• br Materials and methods br

  2018-10-20

  

  Materials and methods Results and discussion To generate an OKSM mouse model with higher reprogramming efficiency we exchanged the m2rtTA for the more efficient rtTA3 (Das et al., 2004). We used founder animals which can be found commercially available at the Jackson Institute and applied a br

• The transgenic iPSCs differentiate into embryoid

  2018-10-20

  

  The transgenic iPSCs differentiate into embryoid bodies (EBs) containing spontaneously beating EGFP-positive areas, which first appear on day 7–9 of differentiation (Fig. 2A). After 7days of puromycin treatment, nearly all non-cardiomyocytes in EBs are eliminated and the resistant h2 agonist surviv

• The dedifferentiation of lineage committed cells

  2018-10-20

  

  The dedifferentiation of lineage-committed Cell Cycle Compound Library into more primitive stem-like states during transplantation is similar to the cell-state transitions that occur during tumor initiation (Keller et al., 2010). For example, preceding the onset of basal cell carcinoma, adult tumor-

• Whole exome sequencing of tumor

  2018-10-20

  

  Whole-exome sequencing of tumor DNA from GBM 5 identified a total of 32 SNVs (Table S3). A subset of these SNVs was selected for single-cell analysis based on putative gene function and variant allele fractions encompassing high, low, and intermediate frequencies. The genomic targets selected includ

• Human leukocyte class I HLA I molecules are

  2018-10-20

  

  Human leukocyte class I (HLA-I) molecules are critical for antigen presentation to CD8+ cytotoxic T-lymphocyte (Garrido et al., 1993), and are understood to be widely expressed on the cell surface of all normal human tissues (Daar et al., 1984). However, HLA-I expression has been reported to be abse

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement n.602300 (SYBIL) to A.V., PRIN Project 20102M7T8X_003 to A.V., Ricerca Finalizzata from Min

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