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Sensory gating describes a filter mechanism protecting the
2019-07-25
‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits aspirin solubility to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2003).
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br Roles for intracellular chloride channels
2019-07-25
Roles for intracellular chloride channels Specific chloride channel proteins in intracellular membranes Concluding remarks Introduction The sulfonylurea derivative glybenclamide (GLYB) is used as oral hypoglycemic agent to treat non-insulin dependent diabetes mellitus [1], [2]. The antid
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Despite many studies having demonstrated the
2019-07-25
Despite many studies having demonstrated the importance of connexin43 (Cx43), the most abundant connexin in bone cells, for bone development and turnover during the last decade [27], little is currently known about GJIC and Cx43 in primary bone tumors. In this report, we analyzed the specific role o
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Previous work examining the link between the COMT gene
2019-07-24
Previous work examining the link between the COMT gene and ISV is limited and has produced contradicting results. The Val allele was linked with higher ISV of RTs following target trials in a continuous performance task (Stefanis et al., 2005) and with higher ISV of RT and P3b latencies of unfamilia
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While a number of studies
2019-07-24
While a number of studies have helped elucidate the principles of target amino group specificity, UBL selectivity, and Ub stock dilution calculator specificity [3], [4], [9], [10], [14], [19], [20], [23], [24], [33], [34], [37], [38], [39], [40], [41], the role of the canonical E2-RING interface in
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br Progestogens and venous thromboembolism
2019-07-24
Progestogens and venous thromboembolism: clinical data Progestogens and haemostatis: biological studies For many years, the effect of HT on haemostatis has been largely investigated in observational studies as well as in high evidence level studies among users of oral and transdermal estrogens
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br Methods br Results and discussion br Conclusions br
2019-07-24
Methods Results and discussion Conclusions Conflict of interest Acknowledgment The research is supported by the National Natural Science Foundation of China (Grant No. U1603285). Overview of the MAPK pathway The mitogen-activated protein kinases (MAPK) pathway, often known as a ca
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br Experimental section br Notes
2019-07-24
Experimental section Notes PDB ID codes The atomic coordinates and structure factors of hDHODH in complex with compounds 4 (PDB id: 5MVC), 5 (PDB id: 5MVD) and 6 (PDB id: 5MUT) have been deposited in the RCSB Protein Data Bank. Acknowledgements This research was financially supported by
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SGC707 for The role of ARA cyp metabolites in the liver is
2019-07-24
The role of ARA-cyp450 metabolites in the liver is still unclear [44]. However, ARA-cyp450 genes metabolize other fatty acids such lauric and palmitic SGC707 for [45]. It was found that decreased cyp4a expression caused fatty livers through reduction of fatty acid metabolism [46]. In this study, we
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br Results br Discussion br Experimental
2019-07-24
Results Discussion Experimental Procedures Author Contributions Acknowledgments Introduction Excitatory synaptic transmission within the brain is largely mediated by ionotropic glutamate receptors. At glutamatergic synapses, α-amino-3-hydroxy-5-methylisoxazole-4-proprionic Biotin-H
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While we are taking full responsibility for
2019-07-24
While we are taking full responsibility for any remaining errors and shortcomings of the paper, we would like to thank Dr. Jong-Hyeon Jeong, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, for offering us insight and literature pointers useful in our quest to
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br Materials and methods br Results br
2019-07-24
Materials and methods Results Discussion In this study, we confirmed the activation of Akt by udenafil in 3T3-L1 cells. To elucidate the underlying mechanism of udenafil, we focused on the mitochondria. Our findings demonstrated that udenafil improved mitochondrial function and expression o
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br Activatable bioorthogonal reactions reagents br Cycloprop
2019-07-23
Activatable bioorthogonal reactions/reagents Cyclopropenes as bioorthogonal reagents for IEDDA substrates Cyclopropenes have become popular bioorthogonal reagents due to their small size, inertness to biological nucleophiles, ability to be genetically encoded (Yu et al., 2012), and participati
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br Results br Discussion Mucosal barriers are constitutively
2019-07-23
Results Discussion Mucosal barriers are constitutively challenged by various stimuli, and the homeostasis of mucosal barriers both at steady state and upon challenge are maintained by tissue-resident immune Phorbol 12,13-dibutyrate for (Kurashima et al., 2013, Okumura and Takeda, 2016). ILC3s
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br Results br Discussion It has been thought that
2019-07-23
Results Discussion It has been thought that commitment to the plasma cell fate begins while DIDS are still in the GC (Suan et al., 2017, Victora and Nussenzweig, 2012), but the main obstacle to test this model and, if correct, to clarify how the plasma cell-prone GC cells develop has been our
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