• Importantly our in vivo data fit to the

  2020-08-13

  

  Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 T7 High Yield Fluorescein RNA levels. The doses of XJD used were based on our previous in vivo study (Zh

• Related with the studies by Zizza et

  2020-08-13

  

  Related with the studies by Zizza et al. described above [66], work by Ward et al. [68] suggested that the C2 domain of cPLA2α, which binds to zwitterionic membranes with high affinity in a Ca2+-dependent manner, has a high membrane remodeling activity, producing dramatic changes in membrane curvatu

• am630 br DUBs in regulation of critical steps in tumor metas

  2020-08-13

  

  DUBs in regulation of critical steps in tumor metastasis Tumor metastasis comprises a complicated series of biological processes in terms of the invasion-metastasis cascade that requires cancer am630 to (1) migrate and invade from the origin sites through the extracellular matrix (ECM) to the st

• DGK is highly expressed in skeletal muscle

  2020-08-13

  

  DGKδ is highly expressed in skeletal muscle [7], which is a primary target of insulin for glucose disposal [14]. Notably, Chibalin et al. reported that DGKδ contributes to hyperglycemia-induced peripheral insulin resistance and that decreased protein levels of DGKδ in skeletal muscle attenuated glu

• Another important mediator in fear

  2020-08-13

  

  Another important mediator in fear learning is the neuropeptide corticotropin-releasing factor (CRF). For example, local repeated administration of CRF into the basolateral amygdala potentiates the acquisition of cue-conditioned fear (Bijlsma et al., 2011) and CRF1 receptor antagonists effectively b

• Conclusions br Acknowledgements The study was supported by a

  2020-08-13

  

  Conclusions Acknowledgements The study was supported by a grant from the Argentine National Agency for the Promotion of Science and Technology (ANPCyT) (PICT 2012-2649). N.R.S., H.H.O., G.J.H. and F.R. are research career members and N.C.G., E.A., E. H., F.M.R., are fellows of the National Scien

• br Conclusions Enzyme can be delivered to the tumour

  2020-08-13

  

  Conclusions Enzyme can be delivered to the tumour by using humanised or fully human bromophenol blue or even loaded into synthetic nanospheres produced from silica [64] or liposomally entrapped [65]. For any future ADEPT developments, a number of basic points need to be considered. As immunogeni

• Though limited to a large cohort of self reported

  2020-08-13

  

  Though limited to a large cohort of self-reported healthy individuals, associations between individual BIBW2992 receptor have been identified which may be clinically significant. Though slight, there is a relationship between the CYP2D6-inferred metabolizer phenotype and the diplotype-predicted acti

• In anticipation of an approach

  2020-08-12

  

  In anticipation of an approach based on modification of the cyclohexylacetic nk1 receptor subunit of 1 as a means of improving permeability, a set of analogs were prepared to map out the optimum display of the acidic functionality. Homologated acids 25 and 26 were found to be equipotent to 1, altho

• br Experimental section br Results

  2020-08-12

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised ro bio 2 did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient by al

• To study systemic potential of the

  2020-08-12

  

  To study systemic potential of the selected compounds as EP1 receptor antagonist, they were evaluated with regard to the sulprostane-induced increase of intravesical bladder pressure in rats. Some of the analogs, 13 and 15–17, which were selected on the basis of their in vitro EP1 receptor affinity,

• These studies suggested that PV PVH might promote bone

  2020-08-11

  

  These studies suggested that PV/PVH might promote bone formation activities and/or inhibit bone resorption activities probably due to its anti-inflammation activity; however, the underlying mechanism remained unknown. Furthermore, it is unclear if PVH shows better activity than that of PV; this is i

• The all NTP pyrophosphatase and

  2020-08-11

  

  The all-α NTP pyrophosphatase and NUDIX families maintain the deoxynucleotide triphosphate (dNTP) pool balance, limit the incorporation of harmful nucleotides, and represent a promising therapeutic approach to develop anticancer and immunosuppressive agents., , , , Among these housekeeping enzymes

• br Materials and methods br Results br

  2020-08-11

  

  Materials and methods Results Discussion Cysteine proteases are upregulated under oxidative stress and play an important role in the preservation of cellular metabolism (Usui et al., 2007). Cysteine proteases are also important under abiotic stresses for plants to degrade proteins denatured

• It is worth mentioning that in this study

  2020-08-11

  

  It is worth mentioning that, in this study we only observed the responses of CYP450 to the short-term exposure of DSP toxins (12 h). However, the toxic effects of DSP toxins to bivalves appeared to abate with longer exposure (Pinto-Silva et al., 2005; Flórez-Barrós et al., 2011; Prego-Faraldo et al.

15916 records 791/1062 page Previous Next First page 上5页 791792793794795 下5页 Last page