• br Acknowledgements This work was supported by

  2021-05-26

  

  Acknowledgements This work was supported by grants from Agence Nationale de la Recherche (ANR CAPHE) and from Ligue contre le Cancer. We acknowledge the continuous support of CNRS and the University of Strasbourg. We thank the technical assistance of the “Plateforme de Chimie Intégrative de Stras

• In a recent study Tomkins et al analyzed

  2021-05-26

  

  In a recent study, Tomkins et al. [7] analyzed the protein-protein interaction network of ROCO proteins. Based on a database analysis, and only taking into account interactions reported in at least two peer-reviewed papers and/or confirmed by two different methods, 113 interactors were revealed for

• br Material and methods br Results br Discussion Monomeric C

  2021-05-26

  

  Material and methods Results Discussion Monomeric CDK5 shows no enzymatic activity and requires the association with a regulatory partner for activation (Dhavan and Tsai, 2001). Here, we found that CDK7 might be one of the partners required for activation of CDK5 in the skin tissue, based o

• In general accurate results for the

  2021-05-26

  

  In general, accurate results for the prediction of the solubility in scCO2 + cosolvents using the CPA-EoS were verified. ALD values for each solute (Table 1) varied from 0.04 to 1.5. Few solutes, such as lauric acid, myristic acid, hydroquinone and salicylic acid, presented the highest ALD values. A

• br Author Contributions br Funding

  2021-05-26

  

  Author Contributions Funding Canadian Institutes of Health Research, operating grant NMD-83126 and the internal funding from the National Research Council Canada, Charlottetown, PE, Canada. Disclosure Statement Acknowledgements Introduction Cholesterol is an essential structural comp

• Cell swelling stimulates the release of certain amino acids

  2021-05-26

  

  Cell swelling stimulates the release of certain amino acids, in particular the non-protein amino p97 taurine, via a pathway which has the characteristics of a channel rather than a carrier [54], [69]. Indeed, on the basis of pharmacological inhibition, it was suggested that volume-activated taurine

• br Conclusions br Acknowledgment br

  2021-05-26

  

  Conclusions Acknowledgment Introduction The role of cholesterol metabolism during multiple sclerosis (MS) is debated and the underlying physiopathology largely unknown. Dyslipidaemia is associated with worsening inflammatory activity and MS disease progression [1], [2], [3]. In the mouse mo

• Dipeptidyl peptidase inhibitors DPP is or gliptins

  2021-05-25

  

  Dipeptidyl peptidase-4 inhibitors (DPP-4is or gliptins) stimulate both post-meal insulin secretion and inhibit 5-Methyl-UTP secretion in a glucose-dependent manner, rendering the risk of hypoglycaemia minimal [10]. They are weight-neutral or may even induce slight weight loss. Their good efficacy h

• br DNA end processing enzymes

  2021-05-25

  

  DNA end processing enzymes The simplest DSB is one that consists of two blunt DNA ends as these termini can be re-joined without processing. However, DSBs induced by ionizing radiation and reactive oxygen species are notorious for producing DNA ends which are non-ligatable (“dirty ends”) and thus

• Interest in DGKs increased as it became clear

  2021-05-25

  

  Interest in DGKs increased as it became clear that not only are they important for lipid homeostasis, they serve to modulate the relative levels of diacylglycerol (DAG) and phosphatidic Cynomolgus Erythropoietin / EPO Protein (His Tag) (PtdOH) that play critical roles in a variety of signaling path

• The genes corresponding to TVAG TVAG TVAG TVAG

  2021-05-24

  

  The genes corresponding to TVAG_263740, TVAG_487600, TVAG_282090, TVAG_170370, and TVAG_148010 seem to be the less expressed, and undetectable by proteomics approach. In comparison, in other T. vaginalis strains, and experimental conditions, they show very few or null EST's reports [4]. Concludin

• Upon Edn ligand binding endothelin receptors can induce

  2021-05-24

  

  Upon Edn ligand binding, endothelin receptors can induce a variety of intracellular signaling cascades leading to diverse cellular responses such as contraction in the case of smooth muscle cells, or cell growth and mitogenesis. Ednrs are expressed in a variety of cell types and tissues, for example

• The role of activation of xenosensor nuclear receptors such

  2021-05-24

  

  The role of activation of xenosensor nuclear receptors such as PPARα, CAR, and PXR in producing hepatomegaly and liver tumors in rodents has been well-established (Klaunig et al., 2003, Lake, 2009). In the case of PPARα, the increase in liver weight results from increased peroxisomal mass and expans

• br Introduction Increasing investigations show that the

  2021-05-24

  

  Introduction Increasing investigations show that the earthworm extract has various beneficial pharmacological activities, including fibrinolytic [2] and anticoagulative activity [3], anti-inflammatory activity [4], anti-oxidative activity [5], [6], peripheral nerve regeneration [7], bone regenera

• Although CCR expression clearly identifies MBC precursors wi

  2021-05-24

  

  Although CCR6 expression clearly identifies MBC precursors within the GC, we found that the expression of this chemokine receptor by responding mglur antagonist was not required for MBC differentiation and had no detectable impact on the GC subsets analyzed in this study. Although this is in agreeme

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