• br Conflicts of interest br Acknowledgment br Introduction T

  2021-11-30

  

  Conflicts of interest Acknowledgment Introduction The caudatin growth factor receptors (FGFRs) are a family members of receptor tyrosine kinase (RTK) that represent attractive therapeutic targets for anti-cancer therapy gaining more and more attention in recent years [1], [2]. This family m

• In enzyme assays it is

  2021-11-30

  

  In enzyme assays, it is convenient to quantify the product formed in the enzyme reaction, where a decrease in the concentration of product indicates enzyme inhibition [35], [36], [37], [38]. In the present study, substrates were carefully chosen so that they are specific to each enzyme. Known natura

• Adox australia Introduction Ventilator induced lung injury V

  2021-11-30

  

  Introduction Ventilator-induced lung injury(VILI) is the most common complication in the mechanical ventilation in clinic. Repetitive opening and closing of Adox australia at high pressures during artificial ventilation would generate shear stress and then lead to the damage of cell junction and d

• Histamine which was used as the agonist

  2021-11-30

  

  Histamine, which was used as the agonist, had low potencies in our functional experiments when compared to its affinity from binding studies (e.g. Lim et al., 2005). This phenomenon is related to the fact that the coupling of the presynaptic receptor to the transduction machinery and the final funct

• Long non coding RNAs lncRNAs are a class

  2021-11-30

  

  Long non-coding RNAs (lncRNAs) are a class of RNA transcripts which are over 200 nucleotides in length and not translated into proteins (Ponting et al., 2009). Recent studies showed that lncRNAs have been identified as crucial regulators of gene expression, chromatin remodeling, and cell cycle (Wahl

• In hypoxic breast cancer cells BNIP

  2021-11-30

  

  In hypoxic breast cancer cells, BNIP3-mediated autophagy activation and elevation of amino Pifithrin-μ levels were notable. BNIP3, a BCL-2 family protein, is known to be transcriptionally regulated by HIF-1α and to be involved in cancer cell death in hypoxic conditions [51]. As a link to autophagy,

• In humans polymorphisms in the lengths of GT sequences from

  2021-11-30

  

  In humans, polymorphisms in the lengths of GT sequences (from 11 to 40) within the HMOX1 promoter impact the magnitude of HO-1 expression profiles. Long GT repeats code for less stable (Z-conformational) DNA with blunted transcriptional activity resulting in lower resting and stimulated HO-1 protein

• In the present referred patients with hemochromatosis and HF

  2021-11-30

  

  In the present referred patients with hemochromatosis and HFE p.C282Y homozygosity, eight of the ten patients with HCV infection were men. In another US cohort of ten patients with HFE p.C282Y homozygosity, chronic HCV infection, and stage 3 or 4 fibrosis, all were men [30]. In the present post-scre

• CONUT score is an effective

  2021-11-30

  

  CONUT score is an effective detector of predicting OS and RFS in HCC patients. We found that patients with a damaged immune-nutrition status had significantly poor OS and RFS. Our initial literature review also retrieved other studies evaluating the survival of HCC patients using CONUT score [36,48,

• Preliminary analyses of these identified two

  2021-11-30

  

  Preliminary analyses of these identified two bands for MALDI-TOF/TOF have shown the presence of approximately 20 proteins, most of which have not yet been characterized. However, several proteins, such as cytochrome c oxidase [53], peroxiredoin II E [54] and alcohol dehydrogenase [55], have been id

• The neuronal glycine receptor HSOR allopregnanolone pathway

  2021-11-29

  

  The neuronal glycine receptor/3α-HSOR/allopregnanolone pathway may also be extended to the central nervous effects of gelsemine and koumine in brain. 3α-HSOR is expressed in certain brain regions in rats and humans, such as the limbic system including hypothalamus, hippocampus and amygdala, in addit

• br Introduction Glucokinase GCK hexokinase

  2021-11-29

  

  Introduction Glucokinase (GCK, hexokinase IV) is a monomeric enzyme that catalyzes the ATP-dependent conversion of glucose to glucose 6-phosphate, the first and rate-limiting step of glycolysis in the liver and pancreas [1,2]. GCK was first discovered in the early 1960's, and shortly thereafter i

• Unlike our present results in week old months

  2021-11-29

  

  Unlike our present results in 4–12-week-old (~1–3 months) females, where a high-fat-diet-induced increase in body weight was evident, Schmidt et al. exposed male glut3 mice to a similar high-fat diet (60% kilocalories from fat) and observed no change in body weight, plasma glucose or insulin concent

• The effect of GCK NES mutations on

  2021-11-29

  

  The effect of GCK-NES mutations on enzyme kinetics and protein stability might account for the hyperglycaemia that characterizes MODY2 patients, since reduced GCK activity would increase the threshold for glucose stimulated insulin release in beta-cells [31,37,49]. However, a more in depth functiona

• Cortisol targets many organs and tissues and

  2021-11-29

  

  Cortisol targets many organs and tissues and has certain effects on metabolism, including promoting glycolysis. It can cross the blood nisoldipine barrier and act centrally to regulate HPA axis activity by activating negative feedback mechanisms effectively, cortisol inhibits its own production (Fai

16086 records 538/1073 page Previous Next First page 上5页 536537538539540 下5页 Last page