• br STAR Methods br Introduction Arsenite is a well

  2022-08-13

  

  STAR★Methods Introduction Arsenite is a well-recognized toxic metalloid that commonly presents in the natural environment. Chronic exposure to arsenite can lead to a wide range of adverse health effects to human, including cancers, cardiovascular diseases, diabetes, skin lesion and neurodegene

• br Role of ferroptosis in PD Pathological progression of

  2022-08-13

  

  Role of ferroptosis in PD Pathological progression of PD displays features that may facilitate ferroptosis induction such as elevated iron in the SNpc [49], [57], [88], [122], depleted GSH [194] and lipid peroxidation [51]. Iron chelation has been shown to mitigate the motor impairment in mouse m

• br Materials and methods br Results and

  2022-08-13

  

  Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa BAY 41-2272 to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in the total ce

• Syringe services programs SSPs as well as

  2022-08-13

  

  Syringe services programs (SSPs), as well as expanded HIV and hepatitis C virus (HCV) testing, are key components of harm reduction for PWID and can reduce HIV and hepatitis C virus (HCV) transmissions in this Calcein AM receptor [14], [15], [16]. The number of SSPs has increased in recent years in

• RK-33 receptor We also evaluated the effect

  2022-08-13

  

  We also evaluated the effect of varying ionic strength. These experiments included previously characterized H3 (residues 1–21) and SNAIL (residues 1–9) peptides [8], [34] to allow a comparative analysis with different ligands (Fig. 1A). As shown in Fig. 2 and listed in Table 2, it is evident that a

• br Methods br Acknowledgements We are grateful to Eric Olson

  2022-08-13

  

  Methods Acknowledgements We are grateful to Eric Olson for providing Yap/Taz floxed mice, and to members of the Epstein lab for helpful comments and advice. This work was supported by NIH R01 HL118768, R35 HL140018, the Cotswold Foundation and the WW Smith Endowed Chair to J.A.E. The Hippo

• In fact most PIs are susceptible

  2022-08-12

  

  In fact, most PIs are susceptible to substitutions at Asp168, which are often present in patients who fail therapy (Pawlotsky, 2016). Notably, the polymorphism Gln168 at this position underlies reduced efficacy of PIs against GT3 (Soumana et al., 2016a). Glecaprevir and voxilaprevir have improved re

• Introduction Hepatocellular carcinoma HCC is the fifth most

  2022-08-12

  

  Introduction Hepatocellular carcinoma (HCC) is the fifth most lethal malignant tumor worldwide and is the second leading cause of cancer-related death [1]. For HCC patients, A23187, free acid virus (HBV) infection is the important causative risk factor in Asia-Pacific regions [[2], [3], [4]]. In C

• A more quantitative view of kinase specificity suggests

  2022-08-12

  

  A more quantitative view of kinase specificity suggests a continuum of phosphorylation rates for the various substrates of a particular kinase (Figure 4A). Such differences in ‘substrate quality’ can arise from variations in phosphorylation site or docking sequences and may explain why the timing or

• CgtA is involved in stringent response and it

  2022-08-12

  

  CgtA is involved in stringent response and it interacts with SpoT to maintain optimal (p)ppGpp/ppGpp quotient in bacteria. Depletion of CgtA results in increased ppGpp levels [8]. CgtA is also important for cellular development [12] and involved in synchronization of DNA replication initiation and c

• However a direct effect of ROS

  2022-08-12

  

  However, a direct effect of ROS on GSNOR has also been described. Inhibition of GSNOR by ROS has been demonstrated for yeast [44], Arabidopsis[36], and Baccaurea ramiflora (Burmese grape) [45] suggesting that this could be a general mechanism of crosstalk between ROS and ·No signaling. Interestingly

• tnf-a In plants NO production is one of the early responses

  2022-08-12

  

  In plants, NO production is one of the early responses to stress (Tossi, Lamattina, & Cassia, 2009). Usually, NO signal transduction requires the involvement of downstream signaling compounds. We further investigated the effects of cGMP on GSK-3 expression. The data showed that LY83583 (a cGMP inhib

• We recently reported that the human

  2022-08-12

  

  We recently reported that the human-derived PancCa cell line PANC-1 and the human-derived hepatocellular HepG2 cell line express GPR55 mRNA and protein [21]. In PANC-1 and HepG2 cells, knockdown of GPR55 with specific siRNAs abrogates cellular uptake of Tocrifluor 1117, a selective GPR55 ligand [21]

• The treatment target which aims at

  2022-08-12

  

  The “90-90-90 treatment target” which aims at diagnosing 90% of HIV-infected individuals, treating 90% of those diagnosed and achieve viral suppression for 90% of treated individuals, is a key strategy to achieve one of the sustainable development goals (SDG) of ending AIDS as a public health threat

• AFB Fapy dG has been long recognized as a substrate

  2022-08-12

  

  AFB1-Fapy-dG has been long recognized as a substrate for nucleotide excision repair [24,25]. However, we recently demonstrated that this lesion is removed by Phorbol 12,13-dibutyrate excision repair. We showed that DNA glycosylase NEIL1, a member of the Fpg/Nei glycosylase family, could excise AFB1

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