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br Conclusions br ISG is an
2019-07-26
Conclusions ISG15 is an ubiquitin‐like protein that is induced by treating mammalian PSB 0777 ammonium salt where with interferon‐α/β. UbE1L was identified as the E1‐activating enzyme for ISG15 in the course of experiments that demonstrated that the nonstructural or NS1 protein of influenza B v
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Consistent with the known tolerance of the Suzuki Miyaura
2019-07-25
Consistent with the known tolerance of the Suzuki–Miyaura reaction to a wide range of aryl substituents, we subsequently found that the commercially available 3-hydroxyphenylboronic TCS 2510 pinacol ester () could be coupled to , to give directly and in comparable yield. Smooth conversion of into
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Predictions of enzyme topology for
2019-07-25
Predictions of enzyme topology for DGAT2 are more difficult since the DGAT2 polypeptide sequences are more diverse across species than those of DGAT1. The length and function of the hydrophilic N-terminus preceding the first hydrophobic segment varies with species – for example, segments in fungi ar
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The lungs dissected from week mice
2019-07-25
The lungs dissected from 4–5-week mice were cut into small pieces and then immersed in Dulbecco\'s modified Eagle\'s medium (Invitrogen, Carlsbad, CA) containing collagenase II (2 mg/ml), trypsin (2.5 mg/ml), Dnase I (2 mg/ml), penicillin (100 U/ml), and streptomycin (100 μg/ml) for 12 hours at 37 °
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br Introduction Natural killer NK
2019-07-25
Introduction Natural killer (NK) cells have an unique ability to directly lyse transformed, virus-infected or stressed cells without prior sensitization or major histocompatibility complex (MHC) class I restriction [1], [2]. They were initially defined and shown to be important effectors of the i
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br Transparency document br Acknowledgments
2019-07-25
Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0
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br Introduction Analyses of genomic
2019-07-25
Introduction Analyses of genomic alterations in cancer have identified epidermal growth factor receptor (EGFR) as one of the most potent “oncogenic driver” kinases that is present in many epithelial tumors including endometrial, breast, prostate, skin, esophagus, lung, stomach, colorectal, and re
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Further studies are needed as continuation of this work to
2019-07-25
Further studies are needed as continuation of this work to explore the effects of type and position of substituents of pyridazinone ring on anti-inflammatory activity profile. Taking into consideration that the phenyl moiety at position 2 wasn\'t a favorable substituent, even certain studies may be
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Sensory gating describes a filter mechanism protecting the
2019-07-25
‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits aspirin solubility to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2003).
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br Roles for intracellular chloride channels
2019-07-25
Roles for intracellular chloride channels Specific chloride channel proteins in intracellular membranes Concluding remarks Introduction The sulfonylurea derivative glybenclamide (GLYB) is used as oral hypoglycemic agent to treat non-insulin dependent diabetes mellitus [1], [2]. The antid
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Despite many studies having demonstrated the
2019-07-25
Despite many studies having demonstrated the importance of connexin43 (Cx43), the most abundant connexin in bone cells, for bone development and turnover during the last decade [27], little is currently known about GJIC and Cx43 in primary bone tumors. In this report, we analyzed the specific role o
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Previous work examining the link between the COMT gene
2019-07-24
Previous work examining the link between the COMT gene and ISV is limited and has produced contradicting results. The Val allele was linked with higher ISV of RTs following target trials in a continuous performance task (Stefanis et al., 2005) and with higher ISV of RT and P3b latencies of unfamilia
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While a number of studies
2019-07-24
While a number of studies have helped elucidate the principles of target amino group specificity, UBL selectivity, and Ub stock dilution calculator specificity [3], [4], [9], [10], [14], [19], [20], [23], [24], [33], [34], [37], [38], [39], [40], [41], the role of the canonical E2-RING interface in
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br Progestogens and venous thromboembolism
2019-07-24
Progestogens and venous thromboembolism: clinical data Progestogens and haemostatis: biological studies For many years, the effect of HT on haemostatis has been largely investigated in observational studies as well as in high evidence level studies among users of oral and transdermal estrogens
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br Methods br Results and discussion br Conclusions br
2019-07-24
Methods Results and discussion Conclusions Conflict of interest Acknowledgment The research is supported by the National Natural Science Foundation of China (Grant No. U1603285). Overview of the MAPK pathway The mitogen-activated protein kinases (MAPK) pathway, often known as a ca
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