• Introduction The onset of uterine labor is

  2022-06-23

  

  Introduction The onset of uterine labor is the culmination of a gradual uterine activation wherein physiological inflammation induces a common prolabor pathway characterized by increased myometrial contractility, weakening of fetal membrane integrity, and cervical ripening. Pathological proinflamma

• It was reported that GPR is expressed

  2022-06-23

  

  It was reported that GPR120 is expressed on macrophages in adipose tissue (Oh et al., 2010). Whether GPR120-positive IWP-2 in human and rat pancreas belongs to macrophages was studied. CD68 is a transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages (Horikawa

• Among the compounds prepared at this stage the

  2022-06-23

  

  Among the compounds prepared at this stage, the cyclopropylmethylenoxy analogue attracted our most attention since it demonstrated particularly good in vitro potency at GlyT1 (16nM), no activity at the GlyT2 isoform up to the highest concentration tested (30μM), good physical properties with modera

• The inhibition of NSAIDs towards GLOI

  2022-06-23

  

  The inhibition of NSAIDs towards GLOI provides a direction for the development of novel effective GLOI inhibitors. Although the inhibitory activity of indomethacin was determined and the interactions between it Z-LEHD-FMK and GLOI were probed by NMR titration experiments, no detailed inhibitory mec

• br Introduction Methylglyoxal MG is a highly

  2022-06-23

  

  Introduction Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite formed in cells mainly by the spontaneous degradation of triose phosphates, glyceraldehyde-3-phosphate, and dihydroxyacetone phosphate (Rabbani and Thornalley, 2012). It exists in a wide range of organisms, including proto

• The results obtained through in vitro in vivo and

  2022-06-23

  

  The results obtained through in vitro, in vivo and in silico corroborated with those presented by other works and indicate that CpMutY is involved in oxidative damage repair in this organism. In this regard, MutY conservation in evolutionarily distant bacteria suggests that this protein plays an imp

• GlyRs are members of the superfamily

  2022-06-23

  

  GlyRs are members of the superfamily of Cys-loop receptors (CLRs) [3]. They form postsynaptic pentameric receptor complexes of α1 and β subunits anchored via the scaffolding protein gephyrin [4]. GlyRs are composed of several domains with the large N-terminal extracellular domain (ECD) important for

• Glial cells have emerged as important protagonists of the ce

  2022-06-23

  

  Glial cells have emerged as important protagonists of the central nervous system (CNS) physiology (Chen and Swanson, 2003; Kettenmann and Verkhratsky, 2008; Parpura and Verkhratsky, 2012). As widely described in the literature, astrocytes regulate glutamatergic synapses by clearance of glutamate in

• Previous reports have showed that

  2022-06-23

  

  Previous reports have showed that the expression and localization of GLUT8 in mouse (Gómez et al., 2006; Kim and Moley, 2007), rat (Ibberson et al., 2002) and human (Schürmann et al., 2002). In this study, GLUT8 protein mainly localized in the spermatocytes, elongated and round spermatids in the adu

• br Conflict of interest statement br Acknowledgements This w

  2022-06-23

  

  Conflict of interest statement Acknowledgements This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grants [1061044], [1065410] and [1126857], and NHMRC program grant [1055134]); P.M.S. and A.C. are NHMRC Principal and Senior Principal Rese

• The most classic case of acquired and relapsing epilepsy

  2022-06-22

  

  The most classic case of acquired and relapsing epilepsy is temporal lobe epilepsy (TLE), which originates from the hippocampal formation, a structure situated in the mesial temporal lobe (Majores et al., 2007). Our experiment used the prominent pilocarpine-induced TLE model. Systemic administration

• To date types of glucose transport protein have been discove

  2022-06-22

  

  To date, 14 types of glucose transport protein have been discovered, each having its own specific functions with different distributions [33]. Among these, GLUT4 is particularly important for maintaining glucose metabolism homeostasis and insulin sensitivity, since it is involved in glucose transpor

• br Introduction The mammalian skin forms the largest organ

  2022-06-22

  

  Introduction The mammalian skin forms the largest organ of the body and includes a network of cutaneous nerves, cells of the immune system, and mediators of the neuro-endocrine axis (Theoharides et al., 2016). Analogous to the hypothalamic-pituitary-adrenal axis, neuropeptides and their receptors

• To date the underlying mechanism of ropivacaine in inducing

  2022-06-22

  

  To date, the underlying mechanism of ropivacaine in inducing neurotoxicity remains unclear. Cell death was intimately involved in local-anesthetic neurotoxicity [6,18]. Two classic signaling pathways triggered cell death: the extrinsic pathway and the intrinsic pathway [12]. Our study demonstrated t

• br Place in Therapy In the case of

  2022-06-22

  

  Place in Therapy In the case of minor bleeding, the anticoagulant effects of all FXa inhibitors except betrixaban, which has a longer half-life, will diminish within 24-48 hours of discontinuation of the drug provided the patient has normal renal function. In these cases stopping the FXa inhibito

15256 records 361/1018 page Previous Next First page 上5页 361362363364365 下5页 Last page