• We designed SSOs that block APP

  2023-09-07

  

  We designed SSOs that block APP exon 17 splicing and induce the production of an alternatively spliced APP mRNA lacking exon 17 (APPΔex17). APPΔex17 mRNA encodes an APP protein isoform that lacks 49 glycoprotein inhibitors including the γ-secretase cleavage sites that give rise to the toxic, AD-asso

• ephrin receptor AMPK is a central regulator of cell growth m

  2023-09-07

  

  AMPK is a central regulator of cell growth, migration, metabolism, autophagy, and cell polarity [20], [21], [22], [23]. It is highly conserved in eukaryotes and functions as the primary sensor of intracellular adenosine nucleotides [24]. When intracellular ATP levels decrease, AMPK is activated to g

• In the present study AP B preferentially released

  2023-09-07

  

  In the present study, AP31-B preferentially released hydrophobic inhibitor of catalase such as leucine and alanine from N-terminal of peptide (Fig. 4). The debittering ability of AP31-B seemed to depend on such substrate specificity, but additional tests against other hydrophobic amino acids are ne

• Further validation for a role in LOX pathway

  2023-09-07

  

  Further validation for a role in 12/15-LOX pathway in mediating adipocyte function comes from studies revealing a regulatory role of lipocalin-2 on 12/15-LOX activity. Lipocalin-2, a glycoprotein member of the lipocalin superfamily, is a novel abundant adipokine implicated in obesity-mediated inflam

• The proposed formulation is however

  2023-09-07

  

  The proposed formulation is, however, challenging to solve since the structured sparsity-inducing norms are non-smooth. In order to solve the new objective function, we consider two different approaches: proximal averaging, which takes the average the solutions from the proximal operator for the ind

• Previous studies have demonstrated the presence of soluble N

  2023-09-07

  

  Previous studies have demonstrated the presence of soluble NTPDases, 5′-nucleotidase and adenosine deaminase in rat blood serum as well as in human blood (Doleski et al., 2016; Oses et al., 2004; Yegutkin, 1997; Yegutkin et al., 2007). In addition, our earlier reports have shown that these membrane-

• The pathogenesis of d penicillamine induced MG

  2023-09-07

  

  The pathogenesis of d-penicillamine-induced MG is not clear. The repertoire of anti-AChR Tubacin in d-penicillamine-induced MG has been shown to be similar to that in idiopathic MG in terms of AChR antigenic regions, suggesting a common immune mechanism (Tzartos et al., 1988). About 20% of d-penic

• br Materials and methods All animal experiments were perform

  2023-09-07

  

  Materials and methods All animal experiments were performed using the recommendations of the Guide for the Care and Use of Laboratory Animals (National Research Council, 2011) and approved by the University of Colorado—Denver Institutional Animal Care and Use Committee. Adult male Sprague—Dawley

• MafB a member of the Maf

  2023-09-07

  

  MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in MK-4827 hydrochloride receptor with exogenous expression of MafB (Tillmanns et al., 2007). However, in al

• br Materials and methods br Results

  2023-09-07

  

  Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o

• In our studies of leucine and BCH in pancreatic islets

  2023-09-06

  

  In our studies of leucine and BCH in pancreatic islets and clonal insulin cell lines, we noticed that leucine was a slightly stronger stimulant of insulin release. Previous studies showed that leucine can be metabolized to CO2[11], [12], [13], [14] and can increase acetoacetate in pancreatic islets

• AP activation is known to upregulate downstream target

  2023-09-06

  

  AP-1 activation is known to upregulate downstream target genes including Dexmedetomidine D1, c-myc, Bcl-xl, MMP-9, EGFR, and specific miRNAs that are involved in progression and metastasis of tumors. Moreover, matrix metalloproteinase-2 has been shown as a downstream gene of AP-1, triggered by 15-HE

• We also show that in

  2023-09-06

  

  We also show that in both ATM proficient and deficient/mutant order the activation of ATR signaling is DSB complexity-dependent (Figs. 1, 4A, C and E, 6A and B). Wang et al. have also reported that the effects of ATR and CHK1 on radiosensitivity are independent of the NHEJ repair pathway [41], [42]

• The use of FTAI can overcome

  2023-09-06

  

  The use of FTAI can overcome the negative impact of low estrus detection efficiency, but implies effective synchrony of luteal function as well as synchronous growth and ovulation of a viable pkc inhibitor follicle. Pregnancy rates obtained with FTAI may be comparable or better than those obtained

• This study evaluated the anti

  2023-09-06

  

  This study evaluated the anti-tumor influences of LA against HepG2 mglur in vivro, and investigated the molecular mechanisms of inducing apoptosis. Overall, our studies suggested that LA is a promising anti-cancer drug and a possible novel therapeutic agent directed toward the mitochondrial-mediate

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